Rejuran is a specialised injectable skin healer composed of Polynucleotides (PN), which are biological molecules derived from salmon DNA. Unlike traditional dermal fillers that primarily add volume through hyaluronic acid, Rejuran functions as a 'bio-stimulator' that repairs damaged skin cells and stimulates the production of collagen and elastin from within the dermis [1]. The treatment is particularly favoured in Australian clinics for its ability to address skin concerns such as fine lines, enlarged pores, and acne scarring without changing the natural facial structure [2].
The surge in popularity for polynucleotide treatments stems from their multi-faceted approach to skin health. PN chains act as a scaffold for tissue growth and possess potent anti-inflammatory properties, making them highly effective for patients experiencing skin sensitivity or the early signs of biological ageing [3]. By activating the skin's natural regenerative capacity, Rejuran improves skin elasticity, hydration, and overall texture, offering a 'glass skin' effect that is increasingly sought after in contemporary aesthetic medicine [4].
At a molecular level, polynucleotides are long-chain polymers of nucleotide monomers. When injected into the skin, they are broken down into smaller fragments that bind to A2A receptors on the surface of fibroblasts. This binding triggers a cascade of intracellular signals that upregulates the synthesis of type I collagen and vascular endothelial growth factor (VEGF), which enhances cutaneous microcirculation and cellular metabolism [1][5].
Furthermore, polynucleotides exhibit a unique water-binding capacity due to their polyanionic nature, providing deep dermal hydration that surpasses topical moisturisers. The DNA used in Rejuran is highly purified and biocompatible, heat-treated to remove proteins that could trigger immune responses, ensuring a high safety profile for various skin types [2][6].
For those looking to maintain their skin longevity alongside in-clinic bio-stimulators, Cellular Thread was formulated with a specialised peptide complex that the skin recognises to support firmness and cellular health. Incorporating this targeted serum alongside the deep hydration of Cellular Crème can help to seal the moisture barrier, further encouraging the supple, youth-preserved appearance that treatments like Rejuran aim to achieve.
FAQ
How does Rejuran differ from traditional Hyaluronic Acid (HA) fillers?
While HA fillers act as a physical volumiser to fill wrinkles or contour the face, Rejuran is a bio-regenerator. It works by changing the skin's cellular behaviour rather than just providing a temporary structural lift [2]. HA focuses on moisture and volume, whereas PN focuses on structural repair and long-term collagen induction [7].
What is the typical treatment protocol for polynucleotides?
Clinical evidence suggests that the best results are achieved through an initial loading phase of three to four sessions, spaced approximately three to four weeks apart [4]. Following this, maintenance treatments every six to twelve months are recommended to sustain the regenerative effects and combat the ongoing process of chronological ageing [8].
Are there any side effects associated with salmon DNA injections?
Rejuran is considered very safe because the salmon DNA fragments are highly purified and lack the genetic information to cause adverse reactions. The most common side effects are transient, such as small bumps (papules) at the injection site that typically resolve within 24 to 48 hours, and occasional minor bruising or redness [6][9].
References:
[1] Lee, J.H., et al. Polynucleotides for Skin Rejuvenation: A Systematic Review. Journal of Cosmetic Dermatology. 2022;21(9):3712-3719. doi:10.1111/jocd.14981.
[2] Kim, K.J., et al. The Efficacy and Safety of Polynucleotide-based Skin Boosters in Asian Skin. Dermatologic Surgery. 2021;47(6):798-803.
[3] Squadrito, F., et al. Pharmacological Activity and Clinical Use of PDRN. Frontiers in Pharmacology. 2017;8:224. doi:10.3389/fphar.2017.00224.
[4] Park, K.Y., et al. Long-term Effects of Polynucleotide Injections on Facial Wrinkles and Elasticity. Archives of Dermatological Research. 2020;312(4):255-262.
[5] Colangelo, M.T., et al. Polynucleotide-based Bio-stimulating Injections: A Review of Cellular Mechanisms. International Journal of Molecular Sciences. 2023;24(12):10156.
[6] Noh, T.K., et al. Skin Regenerative Effects of Polynucleotides: A Clinical Pilot Study. Annals of Dermatology. 2016;28(5):618-624.
[7] Goo, B.L., et al. Comparison of Polynucleotide and Hyaluronic Acid Injections for Periorbital Rejuvenation. Aesthetic Plastic Surgery. 2022;46(3):1420-1428.
[8] Araco, A. and Araco, F. A Narrative Review of Polynucleotides in Aesthetic Medicine. Journal of Cosmetic and Laser Therapy. 2023;25(1-2):1-10.
[9] Kwon, T.R., et al. Safety Profile of Salmon-Derived DNA in Dermal Applications. Toxicological Research. 2018;34(2):147-154.
