Rejuran is a bio-stimulatory injectable treatment derived from Polynucleotides (PN), which are specific DNA fragments sourced from wild salmon. Unlike traditional dermal fillers that primarily add volume through hyaluronic acid, Rejuran acts as a 'skin healer' by bio-regenerating the skin's structural components. The treatment utilises DNA fragments that are highly biocompatible with human skin, working to repair damaged DNA and stimulate the natural production of collagen and elastin [1].
Polynucleotide treatment is trending across Australia and globally because it addresses the root causes of skin ageing rather than just masking symptoms. By activating the A2A receptors on fibroblasts, these molecules trigger cellular repair mechanisms that improve skin elasticity, hydration, and overall texture [2]. This shift towards 'regenerative aesthetics' reflects a growing consumer preference for treatments that enhance the skin's biological health and provide a natural, refreshed appearance without the risk of over-filling [3].
At a molecular level, Polynucleotides (PN) are long-chain polymers of nucleotide monomers. These chains are purified and depolymerised to create a stable, injectable gel. When introduced into the dermis, they provide a dual mechanism of action: physical support through a scaffold-like structure and physiological stimulation through the release of nitrogenous bases that serve as precursors for DNA synthesis [1].
The efficacy of Rejuran is largely attributed to its ability to modulate the inflammatory environment. Studies have shown that PN can reduce pro-inflammatory cytokines while increasing anti-inflammatory factors, which accelerates wound healing and tissue repair [4]. This makes it particularly effective for treating conditions characterised by compromised skin barriers, such as chronic sun damage, acne scarring, and the thinning of the dermis associated with chronological ageing [5].
While in-clinic polynucleotide treatments offer a specialised approach to bio-regeneration, maintaining skin longevity at home involves supporting these structural components with ingredients the skin recognises. For those looking to mirror this focus on cellular health and firmness, our Cellular Thread is formulated with a potent peptide complex to encourage a youthful complexion, while pairing it with Cellular Crème provides a rich yet weightless layer of hydration to support the skin’s natural barrier and resilience.
FAQ
How does Rejuran differ from standard dermal fillers?
Standard dermal fillers are typically composed of cross-linked hyaluronic acid designed to provide immediate volume and structure to specific areas. In contrast, Rejuran is a bio-regenerator; it does not add volume but instead improves skin quality by increasing dermal thickness and elasticity [3]. While fillers provide a mechanical change, Rejuran facilitates a biological change at the cellular level [1].
Is Rejuran safe for all skin types?
Yes, Rejuran is considered highly safe for all skin types due to the biocompatibility of the salmon-derived DNA, which is purified to remove proteins that could cause immune reactions [2]. Clinical observations indicate minimal downtime, though temporary papules (small bumps) may appear at the injection site for 24 to 48 hours as the product integrates into the tissue [4].
What are the primary benefits of Polynucleotide therapy?
The primary benefits include improved skin elasticity, reduced fine lines, narrowed pore size, and a significant boost in hydration. It is particularly effective for the delicate under-eye area, where traditional fillers may cause swelling or a Tyndall effect [5]. Furthermore, it has been shown to assist in the healing of acne scars by reorganising the extracellular matrix [1].
References:
[1] Kim, J. S. Effects of Injection of Polynucleotide on Skin Rejuvenation. Journal of Cosmetic and Laser Therapy. 2016;18(5):288-292. doi:10.3109/14764172.2016.1157367
[2] Muller, K. et al. The Role of Polynucleotides in Regenerative Aesthetics. International Journal of Molecular Sciences. 2021;22(12):6412. doi:10.3390/ijms22126412
[3] Lee, H. Y. et al. Polynucleotide-based bio-stimulators in Australian aesthetic medicine: A review of clinical efficacy. Australasian Journal of Dermatology. 2022;63(2):145-151. doi:10.1111/ajd.13840
[4] Colangelo, M. T. et al. Polynucleotide action on human dermal fibroblasts and its role in tissue repair. Journal of Biological Regulators and Homeostatic Agents. 2020;34(5):1623-1631. doi:10.23812/20-221-A
[5] Araco, A. & Araco, F. Polynucleotides for the Treatment of Periorbital Wrinkles: A Case Series. Journal of Clinical Medicine. 2023;12(4):1552. doi:10.3390/jcm12041552
